Target：TTK
Fields：Cell cycle
Gene Name：TTK
Protein Name：Dual specificity protein kinase TTK
Human Gene Id：7272
Human Swiss Prot No：P33981
Mouse Swiss Prot No：P35761
Immunogen：The antiserum was produced against synthesized peptide derived from human TTK around the phosphorylation site of Thr676. AA range:642-691
Specificity：Phospho-TTK (T676) Polyclonal Antibody detects endogenous levels of TTK protein only when phosphorylated at T676.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：TTK;MPS1;MPS1L1;Dual specificity protein kinase TTK;Phosphotyrosine picked threonine-protein kinase;PYT
Molecular Weight(Da)：97kD
Background：TTK protein kinase(TTK) Homo sapiens This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009],
Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Present in rapidly proliferating cell lines.,
Subcellular Location：kinetochore,cytoplasm,spindle,membrane,
Expression：Present in rapidly proliferating cell lines.
