Target：Vimentin

Fields：Epstein-Barr virus infection;MicroRNAs in cancer

Gene Name：VIM

Protein Name：vimentin

Human Gene Id：7431

Human Swiss Prot No：P08670

Mouse Swiss Prot No：P20152

Rat Swiss Prot No：P31000

Immunogen：Synthesized phospho-peptide around the phosphorylation site of human Vimentin (Phospho-Tyr38)

Specificity：This antibody detects endogenous levels of Vimentin at Human:Y38;Mouse:Y38;Rat:Y38, It doesn't reacte with total protein.

Formulation：PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-10000 ELISA: 1:10000

Purification：The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：VIM

Observed Band(KD)：51kD

Background： This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009],

Function：function:Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.,online information:Vimentin entry,PTM:One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized.,sequence caution:Intron retention.,similarity:Belongs to the intermediate filament family.,subunit:Homopolymer. Interacts with HCV core protein. Interacts with LGSN and SYNM.,tissue specificity:Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.,

Subcellular Location：Cytoplasm . Cytoplasm, cytoskeleton . Nucleus matrix . Cell membrane .

Expression：Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.