Target：4.1R
Gene Name：EPB41
Protein Name：Protein 4.1
Human Gene Id：2035
Human Swiss Prot No：P11171
Mouse Gene Id：269587
Mouse Swiss Prot No：P48193
Immunogen：The antiserum was produced against synthesized peptide derived from human EPB41 around the phosphorylation site of Tyr660/418. AA range:626-675
Specificity：Phospho-4.1R (Y660) Polyclonal Antibody detects endogenous levels of 4.1R protein only when phosphorylated at Y660.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：EPB41;E41P;Protein 4.1;P4.1;4.1R;Band 4.1;EPB4.1
Observed Band(KD)：60kD
Background： The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009],
Function：disease:Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.,disease:Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.,function:Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.,PTM:O-glycosylated; contains N-acetylglucosamine side chains in the C-ter
Subcellular Location：Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Nucleus .
Expression： Brain,PCR rescued clones,Reticulocyte,Spleen,
