Target：IL-1RI
Fields：MAPK signaling pathway;Cytokine-cytokine receptor interaction;NF-kappa B signaling pathway;Osteoclast differentiation;Hematopoietic cell lineage;Th17 cell differentiation;Inflammatory mediator regulation of TRP channels;Pathogenic Escherichia coli infection;Shigellosis;Amoebiasis;Human cytomegalovirus infection;Human T-cell leukemia virus 1 infection;Fluid shear stress and atherosclerosis
Gene Name：IL1R1
Protein Name：Interleukin-1 receptor type 1
Human Gene Id：3554
Human Swiss Prot No：P14778
Mouse Gene Id：16177
Mouse Swiss Prot No：P13504
Rat Swiss Prot No：Q02955
Immunogen：The antiserum was produced against synthesized peptide derived from human IL-1Ralpha/CD121alpha around the phosphorylation site of Tyr496. AA range:471-520
Specificity：Phospho-IL-1RI (Y496) Polyclonal Antibody detects endogenous levels of IL-1RI protein only when phosphorylated at Y496.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：IL1R1;IL1R;IL1RA;IL1RT1;Interleukin-1 receptor type 1;IL-1R-1;IL-1RT-1;IL-1RT1;CD121 antigen-like family member A;Interleukin-1 receptor alpha;IL-1R-alpha;Interleukin-1 receptor type I;p80;CD antigen CD121a
Observed Band(KD)：65kD
Background： This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013],
Function：function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds IL1RAP.,
Subcellular Location：Membrane ; Single-pass type I membrane protein . Cell membrane . Secreted .
Expression：Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.
