Target：IGF1R

Fields：EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;MAPK signaling pathway;Ras signaling pathway;Rap1 signaling pathway;HIF-1 signaling pathway;FoxO signaling pathway;Oocyte meiosis;Autophagy - animal;Endocytosis;mTOR signaling pathway;PI3K-Akt signaling pathway;AMPK signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;Focal adhesion;Adherens junction;Signaling pathways regulating pluripotency of stem cells;Long-term depression;Ovarian steroidogenesis;Progesterone-mediated oocyte maturation;Pathways in cancer;Transcriptional misregulation in cancer;Proteoglycans in cancer;Glioma;Prostate cancer;Melanoma;Breast cancer;Hepatocellular carcinoma

Gene Name：IGF1R

Protein Name：Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insuli

Human Gene Id：3480

Human Swiss Prot No：P08069

Mouse Gene Id：16001

Mouse Swiss Prot No：Q60751

Rat Gene Id：25718

Rat Swiss Prot No：P24062

Immunogen：Synthesized phospho derived from human IGF1R (Phospho-Tyr1161)

Specificity：This detects endogenous levels of IGF1R (Phospho-Tyr1161)

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000, ELISA 1:10000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain;Insulin-like growth factor 1 receptor beta chain]

Observed Band(KD)：pro: 155kD, recetor beta: 95kD

Background： This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],

Function：catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.,enzyme regulation:Autophosphorylation activates the kinase activity.,function:This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low a

Subcellular Location：Cell membrane ; Single-pass type I membrane protein .

Expression：Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney.