Target：ICAM-1
Fields：NF-kappa B signaling pathway;Cell adhesion molecules;Natural killer cell mediated cytotoxicity;TNF signaling pathway;Leukocyte transendothelial migration;AGE-RAGE signaling pathway in diabetic complications;African trypanosomiasis;Malaria;Staphylococcus aureus infection;Influenza A;Human T-cell leukemia virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;Epstein-Barr virus infection;Rheumatoid arthritis;Viral myocarditis;Lipid and atherosclerosis;Fluid shear stress and atherosclerosis
Gene Name：ICAM1
Protein Name：Intercellular adhesion molecule 1
Human Gene Id：3383
Human Swiss Prot No：P05362
Mouse Swiss Prot No：P13597
Immunogen：The antiserum was produced against synthesized peptide derived from human ICAM-1 around the phosphorylation site of Tyr512. AA range:479-528
Specificity：Phospho-ICAM-1 (Y512) Polyclonal Antibody detects endogenous levels of ICAM-1 protein only when phosphorylated at Y512.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：ICAM1;Intercellular adhesion molecule 1;ICAM-1;Major group rhinovirus receptor;CD antigen CD54
Observed Band(KD)：57kD
Background： This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008],
Function：function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell a
Subcellular Location：Membrane; Single-pass type I membrane protein.
Expression： Blood,Kidney,Liver,Melanoma,Plasma,
