Target：ALDH3A1

Fields：Glycolysis / Gluconeogenesis;Histidine metabolism;Tyrosine metabolism;Phenylalanine metabolism;beta-Alanine metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Metabolic pathways

Gene Name：ALDH3A1

Protein Name：Aldehyde dehydrogenase dimeric NADP-preferring

Human Gene Id：218

Human Swiss Prot No：P30838

Mouse Swiss Prot No：P47739

Rat Gene Id：25375

Rat Swiss Prot No：P11883

Immunogen：The antiserum was produced against synthesized peptide derived from human ALDH3A1. AA range:236-285

Specificity：ALDH3A1 Polyclonal Antibody detects endogenous levels of ALDH3A1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ALDH3A1;ALDH3;Aldehyde dehydrogenase, dimeric NADP-preferring;ALDHIII;Aldehyde dehydrogenase 3;Aldehyde dehydrogenase family 3 member A1

Observed Band(KD)：50kD

Background： Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008],

Function：catalytic activity:An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.,function:ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homodimer.,tissue specificity:High levels in stomach, esophagus and lung; low level in the liver and kidney.,

Subcellular Location：Cytoplasm .

Expression：High levels in stomach, esophagus and lung; low level in the liver and kidney.