Target：HSF-27

Gene Name：CDK5RAP3

Protein Name：CDK5 regulatory subunit-associated protein 3

Human Gene Id：80279

Human Swiss Prot No：Q96JB5

Mouse Gene Id：80280

Mouse Swiss Prot No：Q99LM2

Rat Gene Id：80278

Rat Swiss Prot No：Q9JLH7

Immunogen：The antiserum was produced against synthesized peptide derived from human CDK5RAP3. AA range:341-390

Specificity：HSF-27 Polyclonal Antibody detects endogenous levels of HSF-27 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CDK5RAP3;IC53;MSTP016;OK/SW-cl.114;PP1553;CDK5 regulatory subunit-associated protein 3;CDK5 activator-binding protein C53;Protein HSF-27

Observed Band(KD)：60kD

Background： This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013],

Function：function:Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1.,PTM:Phosphorylated in vitro by CDK5.,similarity:Belongs to the CDK5RAP3 family.,subunit:Interacts with CDK5R1. This interaction is prevented by the association between CDK5R1 and CDK5RAP3 (By similarity). Interacts with the enteric adenovirus serotype 41 fiber protein.,tissue specificity:Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta.,

Subcellular Location：Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes and associates with microtubules. .

Expression：Ubiquitously expressed (PubMed:12054757, PubMed:10721722). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta (PubMed:12737517).