Target：SPON1

Gene Name：SPON1 KIAA0762 VSGP

Protein Name：Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor)

Human Gene Id：10418

Human Swiss Prot No：Q9HCB6

Mouse Swiss Prot No：Q8VCC9

Rat Swiss Prot No：P35446

Immunogen：Synthesized peptide derived from human protein . at AA range: 210-290

Specificity：SPON1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：88kD

Background：function:Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.,similarity:Contains 1 reelin domain.,similarity:Contains 1 spondin domain.,similarity:Contains 6 TSP type-1 domains.,subunit:Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.,tissue specificity:Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen.,

Function：function:Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.,similarity:Contains 1 reelin domain.,similarity:Contains 1 spondin domain.,similarity:Contains 6 TSP type-1 domains.,subunit:Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.,tissue specificity:Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen.,

Subcellular Location：Secreted, extracellular space, extracellular matrix .

Expression：Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen.