Target：HoxD10

Fields：Proteoglycans in cancer;MicroRNAs in cancer

Gene Name：HOXD10

Protein Name：Homeobox protein Hox-D10

Human Gene Id：3236

Human Swiss Prot No：P28358

Mouse Gene Id：15430

Mouse Swiss Prot No：P28359

Immunogen：The antiserum was produced against synthesized peptide derived from human HOXD10. AA range:291-340

Specificity：HoxD10 Polyclonal Antibody detects endogenous levels of HoxD10 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HOXD10;HOX4D;HOX4E;Homeobox protein Hox-D10;Homeobox protein Hox-4D;Homeobox protein Hox-4E

Observed Band(KD)：32kD

Background： This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008],

Function：developmental stage:Expressed in the developing limb buds.,disease:Defects in HOXD10 are a cause of congenital vertical talus (CVT) [MIM:192950]; also known as "rocker-bottom foot" deformity or congenital convex pes valgus. CVT is a dislocation of the talonavicular joint, with rigid dorsal dislocation of the navicular over the neck of the talus. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity.,function:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.,similarity:Belongs to the Abd-B homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Strongly expressed in the adult male and female urogenital tracts.,

Subcellular Location：Nucleus.

Expression：Strongly expressed in the adult male and female urogenital tracts.