Target：HMOX2

Fields：Porphyrin metabolism;Metabolic pathways;Mineral absorption

Gene Name：HMOX2 HO2

Protein Name：Heme oxygenase 2 (HO-2) (EC 1.14.99.3)

Human Gene Id：3163

Human Swiss Prot No：P30519

Mouse Swiss Prot No：O70252

Rat Swiss Prot No：P23711

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：HMOX2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：34kD

Background：heme oxygenase 2(HMOX2) Homo sapiens Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013],

Function：catalytic activity:Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O.,function:Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.,induction:Heme oxygenase 2 activity is non-inducible.,similarity:Belongs to the heme oxygenase family.,similarity:Contains 2 HRM (heme regulatory motif) repeats.,

Subcellular Location：Microsome membrane ; Single-pass type IV membrane protein ; Cytoplasmic side . Endoplasmic reticulum membrane ; Single-pass type IV membrane protein ; Cytoplasmic side .

Expression： Cerebellum,Intestine,Kidney,Lung,Placenta,