Target：HMG-2
Gene Name：HMGB2
Protein Name：High mobility group protein B2
Human Gene Id：3148
Human Swiss Prot No：P26583
Mouse Gene Id：97165
Mouse Swiss Prot No：P30681
Rat Gene Id：29395
Rat Swiss Prot No：P52925
Immunogen：The antiserum was produced against synthesized peptide derived from human HMGB2. AA range:131-180
Specificity：HMG-2 Polyclonal Antibody detects endogenous levels of HMG-2 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：HMGB2;HMG2;High mobility group protein B2;High mobility group protein 2;HMG-2
Observed Band(KD)：27kD
Background： This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008],
Function：function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,subunit:Component of the SET complex, which also contains SET, ANP32A, APEX1 and NME1. Directly interacts with SET.,
Subcellular Location：Nucleus . Chromosome . Cytoplasm . Secreted . In basal state predominantly nuclear. .
Expression：Expressed in gastric and intestinal tissues (at protein level).
