Target：SLC6A8

Gene Name：SLC6A8

Protein Name：Sodium- and chloride-dependent creatine transporter 1

Human Gene Id：6535

Human Swiss Prot No：P48029

Mouse Gene Id：102857

Mouse Swiss Prot No：Q8VBW1

Rat Gene Id：50690

Rat Swiss Prot No：P28570

Immunogen：The antiserum was produced against synthesized peptide derived from human SLC6A8. AA range:581-630

Specificity：SLC6A8 Polyclonal Antibody detects endogenous levels of SLC6A8 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SLC6A8;Sodium- and chloride-dependent creatine transporter 1;CT1;Creatine transporter 1;Solute carrier family 6 member 8

Observed Band(KD)：70kD

Background： The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],

Function：disease:Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome [MIM:300352]. X-linked creatine deficiency syndrome causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia.,function:Required for the uptake of creatine in muscles and brain.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,tissue specificity:Predominantly expressed in skeletal muscle and kidney. Also found in brain, heart, colon, testis and prostate.,

Subcellular Location：Membrane; Multi-pass membrane protein.

Expression：Predominantly expressed in skeletal muscle and kidney. Also found in brain, heart, colon, testis and prostate.