Target：Actin pan

Fields：Rap1 signaling pathway;Phagosome;Apoptosis;Hippo signaling pathway;Focal adhesion;Adherens junction;Tight junction;Platelet activation;Neutrophil extracellular trap formation;Leukocyte transendothelial migration;Thermogenesis;Regulation of actin cytoskeleton;Thyroid hormone signaling pathway;Oxytocin signaling pathway;Gastric acid secretion;Amyotrophic lateral sclerosis;Bacterial invasion of epithelial cells;Vibrio cholerae infection;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Yersinia infection;Influenza A;Proteoglycans in cancer;Hepatocellular carcinoma;Hypertrophic cardiomyopathy;Arrhythmogenic right ventricular cardiomyopathy;Dilated cardiomyopathy;Viral myocarditis;Fluid shear stress and atherosclerosis

Gene Name：ACTG1

Protein Name：Actin cytoplasmic 2

Human Gene Id：60/71

Human Swiss Prot No：P60709/Q9BYX7/P63261

Mouse Gene Id：11461/11465

Rat Gene Id：81822/100361457

Rat Swiss Prot No：P60711/P63259

Immunogen：The antiserum was produced against synthesized peptide derived from human Actin. AA range:326-375

Specificity：Actin Polyclonal Antibody detects endogenous levels of Actin protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ACTB;Actin; cytoplasmic 1;Beta-actin;POTEKP;ACTBL3;FKSG30;Putative beta-actin-like protein 3;Kappa-actin;POTE ankyrin domain family member K;ACTG1;ACTB;ACTG;Actin, cytoplasmic 2;Gamma-actin

Observed Band(KD)：45kD

Background： This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008],

Function：disease:Defects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYTJ patients manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.,function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.,similarity:Belongs to the

Subcellular Location：Cytoplasm, cytoskeleton . Nucleus . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .

Expression： B-cell lymphoma,Brain,Cajal-Retzius cell,Eye,Fetal brain cortex,Foreskin,Hepatocellular car