Target：SGLT-2

Gene Name：SLC5A2

Protein Name：Sodium/glucose cotransporter 2

Human Gene Id：6524

Human Swiss Prot No：P31639

Mouse Gene Id：246787

Mouse Swiss Prot No：Q923I7

Rat Gene Id：64522

Rat Swiss Prot No：P53792

Immunogen：The antiserum was produced against synthesized peptide derived from human SLC5A2. AA range:101-150

Specificity：SGLT-2 Polyclonal Antibody detects endogenous levels of SGLT-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SLC5A2;SGLT2;Sodium/glucose cotransporter 2;Na(+)/glucose cotransporter 2;Low affinity sodium-glucose cotransporter;Solute carrier family 5 member 2

Observed Band(KD)：73kD

Background： This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015],

Function：disease:Defects in SLC5A2 are the cause of renal glucosuria (GLYS1) [MIM:233100]. GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test.,function:Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.,function:Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.,similarity:Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.,

Subcellular Location：Apical cell membrane ; Multi-pass membrane protein .

Expression： Kidney,