Target：SerpinA6

Gene Name：SERPINA6

Protein Name：Corticosteroid-binding globulin

Human Gene Id：866

Human Swiss Prot No：P08185

Mouse Swiss Prot No：Q06770

Immunogen：Synthesized peptide derived from the Internal region of human SerpinA6.

Specificity：SerpinA6 Polyclonal Antibody detects endogenous levels of SerpinA6 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SERPINA6;CBG;Corticosteroid-binding globulin;CBG;Serpin A6;Transcortin

Molecular Weight(Da)：45kD

Background： This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008],

Function：disease:Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.,function:Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.,online information:Transcortin entry,PTM:Glycosylation in position Asn-260 is needed for steroid binding.,PTM:N-glycosylated; binds 5 oligosaccharide chains.,similarity:Belongs to the serpin family.,tissue specificity:Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.,

Subcellular Location：Secreted.

Expression：Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.