Target：Septin 7

Fields：Shigellosis

Gene Name：SEPT7

Protein Name：Septin-7

Human Gene Id：989

Human Swiss Prot No：Q16181

Mouse Gene Id：235072

Mouse Swiss Prot No：O55131

Rat Gene Id：64551

Rat Swiss Prot No：Q9WVC0

Immunogen：The antiserum was produced against synthesized peptide derived from human SEPT7. AA range:350-399

Specificity：Septin 7 Polyclonal Antibody detects endogenous levels of Septin 7 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000.IHC:1:50-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SEPT7;CDC10;Septin-7;CDC10 protein homolog

Observed Band(KD)：48kD

Background：septin 7(SEPT7) Homo sapiens This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011],

Function：function:Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore.,similarity:Belongs to the septin family.,subcellular location:Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase.,subunit:Heterohexamer composed of two heterotrimers containing one copy each of SEPT2, SEPT6 and SEPT7. The asymmetrical heterotrimers associate head-to-head to form a hexameric unit that assembles into filaments. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPT2, SEPT6 and SEPT7.,

Subcellular Location：Cytoplasm . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cleavage furrow . Midbody . Cytoplasm, cytoskeleton, cilium axoneme . Cell projection, cilium, flagellum . Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase. Associated with actin stress fibers (By similarity). Found in the sperm annulus (PubMed:25588830). .

Expression：Widely expressed.