Target：SEPT4

Fields：Apoptosis;Apoptosis - multiple species

Gene Name：SEPT4 ARTS PNUTL2 SEP4 hucep-7

Protein Name：Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (ARTS) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Cerebral protein 7)

Human Gene Id：5414

Human Swiss Prot No：O43236

Mouse Swiss Prot No：P28661

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：SEPT4 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：52kD

Background：septin 4(SEPT4) Homo sapiens This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010],

Function：function:Involved in cytokinesis .,similarity:Belongs to the septin family.,subcellular location:Only observed in tumor tissue cells.,subunit:May assemble into a multicomponent structure.,tissue specificity:Expressed ubiquitously in adult and fetal tissues with particularly high expression in adult heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancer and malignant melanoma samples.,

Subcellular Location：Cytoplasm . Cell projection, cilium, flagellum . Cytoplasmic vesicle, secretory vesicle . Cell projection, axon . Cell projection, dendrite . Perikaryon . Cell junction, synapse . In platelets, found in areas surrounding alpha-granules (PubMed:15116257). Found in the sperm annulus, a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum (PubMed:25588830). Expressed and colocalized with SLC6A3 and SNCA in axon terminals, especially at the varicosities (By similarity). .; [Isoform ARTS]: Mitochondrion . Nucleus . While predominantly localized in the mitochondria under resting conditions, translocates into the nucleus after TGF-beta treatment and apoptosis induction. .

Expression：Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Expressed in presynaptic terminals of dopaminergic neurons projecting from the substantia nigra pars compacta to the striatum (at protein level) (PubMed:17296554). Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level) (PubMed:17296554). Expressed in the putamen and in the adjacent cerebral cortex (at protein level) (PubMed:17296554). Expressed in colonic crypts (at protein level) (PubMed:30389919). Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets. ; [Isoform ARTS]: Highly expressed in the brain and heart.