Target：SCYL1BP1

Fields：p53 signaling pathway

Gene Name：GORAB

Protein Name：RAB6-interacting golgin

Human Gene Id：92344

Human Swiss Prot No：Q5T7V8

Mouse Gene Id：98376

Mouse Swiss Prot No：Q8BRM2

Rat Gene Id：304923

Rat Swiss Prot No：B1H222

Immunogen：The antiserum was produced against synthesized peptide derived from the N-terminal region of human GORAB. AA range:1-50

Specificity：SCYL1BP1 Polyclonal Antibody detects endogenous levels of SCYL1BP1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GORAB;NTKLBP1;SCYL1BP1;RAB6-interacting golgin;N-terminal kinase-like-binding protein 1;NTKL-BP1;NTKL-binding protein 1;hNTKL-BP1;SCY1-like 1-binding protein 1;SCYL1-BP1;SCYL1-binding protein 1

Observed Band(KD)：45kD

Background：golgin, RAB6 interacting(GORAB) Homo sapiens This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009],

Function：caution:It is uncertain whether Met-1 or Met-26 is the initiator.,disease:Defects in GORAB are the cause of geroderma osteodysplasticum (GO) [MIM:231070]; also known as gerodermia osteodysplastica or Walt Disney dwarfism. GO is a rare autosomal recessive disorder characterized by lax, wrinkled skin, joint laxity and a typical face with a prematurely aged appearance. Skeletal signs include severe osteoporosis leading to frequent fractures, malar and mandibular hypoplasia and a variable degree of growth retardation.,similarity:Belongs to the GORAB family.,subunit:Interacts with SCYL1 (By similarity). Interacts with RCHY1 and RAB6A/RAB6.,

Subcellular Location：Cytoplasm . Golgi apparatus .

Expression： Embryo,Pancreas,Testis,Trachea,