Target：ACOX2
Fields：Primary bile acid biosynthesis;Metabolic pathways;PPAR signaling pathway;Peroxisome
Gene Name：ACOX2
Protein Name：Peroxisomal acyl-coenzyme A oxidase 2 (EC 1.17.99.3) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase)
Human Gene Id：8309
Human Swiss Prot No：Q99424
Mouse Swiss Prot No：Q9QXD1
Rat Swiss Prot No：P97562
Immunogen：Synthesized peptide derived from human protein . at AA range: 270-350
Specificity：ACOX2 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：74kD
Background： The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009],
Function：catalytic activity:(25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oyl-CoA + H(2)O + acceptor = (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor.,cofactor:FAD.,disease:Absent in patients suffering from Zellweger syndrome.,function:Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids.,similarity:Belongs to the acyl-CoA oxidase family.,subunit:Heterodimer.,tissue specificity:Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney.,
Subcellular Location：Peroxisome .
Expression：Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney.
