Target：ACOT2

Fields：Fatty acid elongation;Biosynthesis of unsaturated fatty acids;Metabolic pathways;Ovarian steroidogenesis

Gene Name：ACOT2

Protein Name：Acyl-coenzyme A thioesterase 2 mitochondrial

Human Gene Id：10965

Human Swiss Prot No：P49753

Mouse Swiss Prot No：Q9QYR9

Immunogen：The antiserum was produced against synthesized peptide derived from human ACOT2. AA range:171-220

Specificity：ACOT2 Polyclonal Antibody detects endogenous levels of ACOT2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ACOT2;PTE2;PTE2A;Acyl-coenzyme A thioesterase 2; mitochondrial;Acyl-CoA thioesterase 2;Acyl-coenzyme A thioester hydrolase 2a;CTE-Ia;Long-chain acyl-CoA thioesterase 2;ZAP128

Observed Band(KD)：53kD

Background： This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012],

Function：catalytic activity:Palmitoyl-CoA + H(2)O = CoA + palmitate.,caution:Was originally (PubMed:10944470) thought to be peroxisomal but was later shown (PubMed:16940157) to be mitochondrial.,function:Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs.,similarity:Belongs to the C/M/P thioester hydrolase family.,tissue specificity:Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.,

Subcellular Location：Mitochondrion .

Expression：Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.