Target：AKR1A1

Fields：Glycolysis / Gluconeogenesis;Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Glycerolipid metabolism;Pyruvate metabolism;Metabolic pathways;Biosynthesis of cofactors;Chemical carcinogenesis - reactive oxygen species

Gene Name：AKR1A1

Protein Name：Alcohol dehydrogenase [NADP(+)]

Human Gene Id：10327

Human Swiss Prot No：P14550

Mouse Gene Id：58810

Mouse Swiss Prot No：Q9JII6

Rat Gene Id：78959

Rat Swiss Prot No：P51635

Immunogen：Synthesized peptide derived from AKR1A1 . at AA range: 250-330

Specificity：AKR1A1 Polyclonal Antibody detects endogenous levels of AKR1A1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：AKR1A1;ALDR1;ALR;Alcohol dehydrogenase [NADP(+)];Aldehyde reductase;Aldo-keto reductase family 1 member A1

Observed Band(KD)：37kD

Background： This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011],

Function：catalytic activity:An alcohol + NADP(+) = an aldehyde + NADPH.,function:Catalyzes the NADPH-dependent reduction of a variety of aldehydes to their corresponding alcohols.,similarity:Belongs to the aldo/keto reductase family.,subunit:Monomer.,

Subcellular Location：Cytoplasm, cytosol . Apical cell membrane .

Expression：Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.