Target：AK6

Fields：Purine metabolism;Metabolic pathways;Nucleotide metabolism;Biosynthesis of cofactors;Ribosome biogenesis in eukaryotes

Protein Name：Adenylate kinase isoenzyme 6

Human Gene Id：6880

Human Swiss Prot No：Q9Y3D8

Mouse Gene Id：108143

Mouse Swiss Prot No：Q8VCP8

Rat Gene Id：373541

Rat Swiss Prot No：Q5EB68

Immunogen：The antiserum was produced against synthesized peptide derived from human KAD6. AA range:11-60

Specificity：AK6 Polyclonal Antibody detects endogenous levels of AK6 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TAF9;AK6;CINAP;AD-004;CGI-137;Adenylate kinase isoenzyme 6;ATP-AMP transphosphorylase 6;Coilin-interacting nuclear ATPase protein;hCINAP

Observed Band(KD)：20kD

Background：adenylate kinase 6(AK6) Homo sapiens This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],

Function：regulation of cell growth, chromatin organization, transcription, transcription, DNA-dependent, transcription initiation,RNA elongation, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter,RNA elongation from RNA polymerase II promoter, protein complex assembly, protein amino acid acetylation,regulation of cell size, positive regulation of biosynthetic process, regulation of catabolic process, negative regulation of catabolic process, response to organic substance, regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, negative

Subcellular Location：Nucleus, nucleoplasm. Nucleus, Cajal body. Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.

Expression：Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, chorionic villi and the central nervous system.