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GRPR Polyclonal Antibody
GRPR Polyclonal Antibody
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GRPR Polyclonal Antibody
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经销商客户: ¥214.5
实验室客户: ¥292.5
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商品描述

商品属性

Target:GRPR

Fields:Calcium signaling pathway;Neuroactive ligand-receptor interaction

Gene Name:GRPR

Protein Name:Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)

Human Gene Id:2925

Human Swiss Prot No:P30550

Mouse Swiss Prot No:P21729

Rat Swiss Prot No:P52500

Immunogen:Synthesized peptide derived from part region of human protein

Specificity:GRPR Polyclonal Antibody detects endogenous levels of protein.

Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source:Polyclonal, Rabbit,IgG

Dilution:WB 1:500-2000 ELISA 1:5000-20000

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration:1 mg/ml

Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD):42kD

Background: Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008],

Function:function:Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain.,

Subcellular Location:Cell membrane ; Multi-pass membrane protein .

Expression:Highly expressed in pancreas (PubMed:11245983). Also expressed in stomach, adrenal cortex and brain (PubMed:11245983). In brain, expressed in cells throughout the cortex (PubMed:34610277).

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