Target：GRK 3

Fields：Chemokine signaling pathway;Endocytosis;Hedgehog signaling pathway;Glutamatergic synapse;Olfactory transduction;Morphine addiction

Gene Name：ADRBK2

Protein Name：Beta-adrenergic receptor kinase 2

Human Gene Id：157

Human Swiss Prot No：P35626

Mouse Gene Id：320129

Mouse Swiss Prot No：Q3UYH7

Rat Gene Id：25372

Rat Swiss Prot No：P26819

Immunogen：The antiserum was produced against synthesized peptide derived from human GRK3. AA range:361-410

Specificity：GRK 3 Polyclonal Antibody detects endogenous levels of GRK 3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ADRBK2;BARK2;GRK3;Beta-adrenergic receptor kinase 2;Beta-ARK-2;G-protein-coupled receptor kinase 3

Observed Band(KD)：80kD

Background： The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008],

Function：catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.,function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,

Subcellular Location：Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse .

Expression： Brain,Ovary,