Target：GRIK5

Fields：Neuroactive ligand-receptor interaction;Glutamatergic synapse

Gene Name：GRIK5 GRIK2

Protein Name：Glutamate receptor, ionotropic kainate 5 (Excitatory amino acid receptor 2) (EAA2) (Glutamate receptor KA-2) (KA2)

Human Gene Id：2901

Human Swiss Prot No：Q16478

Mouse Swiss Prot No：Q61626

Rat Swiss Prot No：Q63273

Immunogen：Synthesized peptide derived from human protein . at AA range: 910-990

Specificity：GRIK5 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：107kD

Background： This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Function：function:Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate AMPA NMDA = 1S,3R-ACPD.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Associates with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels. Homomeric associations do not produce any channel activity.,

Subcellular Location：Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Expression： Erythroleukemia,Hippocampus,