Target：LAMA5

Fields：PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Human papillomavirus infection;Pathways in cancer;Small cell lung cancer

Gene Name：LAMA5

Protein Name：Laminin subunit alpha-5

Human Gene Id：3911

Human Swiss Prot No：O15230

Mouse Gene Id：16776

Mouse Swiss Prot No：Q61001

Immunogen：The antiserum was produced against synthesized peptide derived from human LAMA5. AA range:2381-2430

Specificity：Laminin α-5 Polyclonal Antibody detects endogenous levels of Laminin α-5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：LAMA5;KIAA0533;KIAA1907;Laminin subunit alpha-5;Laminin-10 subunit alpha;Laminin-11 subunit alpha;Laminin-15 subunit alpha

Observed Band(KD)：400kD

Background： This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013],

Function：domain:Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer.,function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.,similarity:Contains 1 laminin IV type A domain.,similarity:Contains 1 laminin N-terminal domain.,similarity:Contains 22 laminin EGF-like domains.,similarity:Contains 5 laminin G-like domains.,subcellular location:Major component.,subunit:Laminin-15 complex is an heterotrimer composed of three chains (alpha-5/beta-2/gamma-3) which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.,tissue specificity:Expressed in heart, lung, kidney, skeletal mus

Subcellular Location：Secreted, extracellular space, extracellular matrix, basement membrane. Major component.

Expression：Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.