Target：LFTY1

Fields：TGF-beta signaling pathway;Signaling pathways regulating pluripotency of stem cells

Gene Name：LEFTY1 LEFTB LEFTYB UNQ278/PRO317

Protein Name：Left-right determination factor 1 (Left-right determination factor B) (Protein lefty-1) (Protein lefty-B)

Human Gene Id：10637

Human Swiss Prot No：O75610

Mouse Swiss Prot No：Q64280

Immunogen：Synthesized peptide derived from part region of human protein AA range: 121-170

Specificity：LFTY1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：40kD

Background： This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016],

Function：function:Required for left-right axis determination as a regulator of LEFTY2 and NODAL.,PTM:The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.,similarity:Belongs to the TGF-beta family.,

Subcellular Location：Secreted.

Expression： Colon,Pancreas,Spleen,Teratocarcinoma,