Target：LPCAT2

Fields：Glycerophospholipid metabolism;Ether lipid metabolism;Metabolic pathways

Gene Name：LPCAT2

Protein Name：Lysophosphatidylcholine acyltransferase 2

Human Gene Id：54947

Human Swiss Prot No：Q7L5N7

Mouse Gene Id：270084

Mouse Swiss Prot No：Q8BYI6

Rat Swiss Prot No：P0C1Q3

Immunogen：The antiserum was produced against synthesized peptide derived from human LPCAT2. AA range:321-370

Specificity：LPCAT2 Polyclonal Antibody detects endogenous levels of LPCAT2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：LPCAT2;AYTL1;Lysophosphatidylcholine acyltransferase 2;LPC acyltransferase 2;LPCAT-2;LysoPC acyltransferase 2;1-acylglycerophosphocholine O-acyltransferase;1-alkylglycerophosphocholine O-acetyltransferase;Acetyl-CoA:lyso-platelet-ac

Observed Band(KD)：50kD

Background： This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009],

Function：catalytic activity:Acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.,catalytic activity:Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.,domain:The HXXXXD motif is essential for acyltransferase activity.,enzyme regulation:Acetyltransferase activity is increased following acute inflammatory stimulation by lipopolysaccharide (LPS). Acyltransferase activity is unchanged.,function:Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-alkyl-phosphatidylcholine (PC), a major component of cell membranes and a PAF pre

Subcellular Location：Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Cell membrane ; Single-pass type II membrane protein . Lipid droplet .

Expression： Carcinoma,Fetal kidney,Kidney,