Target：Thrombin R

Fields：Rap1 signaling pathway;Calcium signaling pathway;cAMP signaling pathway;Phospholipase D signaling pathway;Neuroactive ligand-receptor interaction;PI3K-Akt signaling pathway;Complement and coagulation cascades;Platelet activation;Regulation of actin cytoskeleton;Pathogenic Escherichia coli infection;Pathways in cancer

Gene Name：F2R

Protein Name：Proteinase-activated receptor 1

Human Gene Id：2149

Human Swiss Prot No：P25116

Mouse Swiss Prot No：P30558

Immunogen：The antiserum was produced against synthesized peptide derived from human PAR1. AA range:23-72

Specificity：Cleaved-Thrombin R (S42) Polyclonal Antibody detects endogenous levels of fragment of activated Thrombin R protein resulting from cleavage adjacent to S42.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：F2R;CF2R;PAR1;TR;Proteinase-activated receptor 1;PAR-1;Coagulation factor II receptor;Thrombin receptor

Observed Band(KD)：46kD

Background： Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],

Function：function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Platelets and vascular endothelial cells.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Platelets and vascular endothelial cells.