Target：Cathepsin A

Fields：Lysosome;Renin-angiotensin system

Gene Name：CTSA

Protein Name：Lysosomal protective protein

Human Gene Id：5476

Human Swiss Prot No：P10619

Mouse Gene Id：19025

Mouse Swiss Prot No：P16675

Immunogen：The antiserum was produced against synthesized peptide derived from human PPGB. AA range:277-326

Specificity：Cleaved-Cathepsin A 32k (R326) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin A 32k protein resulting from cleavage adjacent to R326.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CTSA;PPGB;Lysosomal protective protein;Carboxypeptidase C;Carboxypeptidase L;Cathepsin A;Protective protein cathepsin A;PPCA;Protective protein for beta-galactosidase

Observed Band(KD)：33kD

Background： This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015],

Function：catalytic activity:Release of a C-terminal amino acid with broad specificity.,disease:Defects in CTSA are the cause of galactosialidosis [MIM:256540]. It is an autosomal recessive disease.,function:Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.,similarity:Belongs to the peptidase S10 family.,subunit:Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.,

Subcellular Location：Lysosome.

Expression： Brain,Liver,Placenta,Platelet,Skin,Uterus,