Target：CLD22

Fields：Cell adhesion molecules;Tight junction;Leukocyte transendothelial migration;Pathogenic Escherichia coli infection;Hepatitis C

Gene Name：CLDN22

Protein Name：Claudin-22

Human Gene Id：53842

Human Swiss Prot No：Q8N7P3

Mouse Swiss Prot No：Q9D7U6

Immunogen：Synthesized peptide derived from part region of human protein AA range: 139-189

Specificity：CLD22 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：24kD

Background： This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. [provided by RefSeq, Aug 2010],

Function：function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,

Subcellular Location：Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .

Expression： Trachea,