Target：CLD14

Fields：Cell adhesion molecules;Tight junction;Leukocyte transendothelial migration;Pathogenic Escherichia coli infection;Hepatitis C

Gene Name：CLDN14 UNQ777/PRO1571

Protein Name：Claudin-14

Human Gene Id：23562

Human Swiss Prot No：O95500

Mouse Swiss Prot No：Q9Z0S3

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：CLD14 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：26kD

Background： Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several

Function：disease:Defects in CLDN14 are the cause of non-syndromic sensorineural deafness autosomal recessive type 29 (DFNB29) [MIM:605608]. DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,tissue specificity:Liver, kidney. Also found in ear.,

Subcellular Location：Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Expression：Liver, kidney. Also found in ear.