Target：CEP57
Gene Name：CEP57
Protein Name：Centrosomal protein of 57 kDa
Human Gene Id：9702
Human Swiss Prot No：Q86XR8
Mouse Swiss Prot No：Q8CEE0
Immunogen：The antiserum was produced against synthesized peptide derived from human CEP57. AA range:241-290
Specificity：CEP57 Polyclonal Antibody detects endogenous levels of CEP57 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CEP57;KIAA0092;TSP57;Centrosomal protein of 57 kDa;Cep57;FGF2-interacting protein;Testis-specific protein 57;Translokin
Observed Band(KD)：50kD
Background： This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple
Function：function:Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2.,similarity:Belongs to the translokin family.,subcellular location:Associates with microtubules and the centrosome.,subunit:Homodimer. Interacts with FGF2 and RAP80. Does not interact with FGF1 or FGF2 isoform 24 kDa.,tissue specificity:Ubiquitous.,
Subcellular Location：Nucleus . Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
Expression：Ubiquitous.
