Target：CEP350

Gene Name：CEP350

Protein Name：Centrosome-associated protein 350

Human Gene Id：9857

Human Swiss Prot No：Q5VT06

Immunogen：The antiserum was produced against synthesized peptide derived from human CEP35. AA range:671-720

Specificity：CEP350 Polyclonal Antibody detects endogenous levels of CEP350 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CEP350;CAP350;KIAA0480;GM133;Centrosome-associated protein 350;Cep350;Centrosome-associated protein of 350 kDa

Molecular Weight(Da)：351kD

Background：centrosomal protein 350(CEP350) Homo sapiens The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008],

Function：function:Required for anchoring microtubules to the centrosomes. Required for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity.,PTM:Phosphorylated during mitosis.,similarity:Contains 1 CAP-Gly domain.,subcellular location:Associated with mitotic spindles. Nuclear, in discrete foci. Associated with intermediate filaments.,subunit:Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with FGFR1OP via its C-terminus. Interacts with NR1H3, PPARA, PPARD and PPARG.,tissue specificity:Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas.,

Subcellular Location：Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Associated with mitotic spindles (PubMed:16314388). Nuclear, in discrete foci. Associated with intermediate filaments (PubMed:15615782). Also present in the pericentrosomal area (PubMed:17878239). Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole (PubMed:28625565). Localizes to the distal end of the centriole on the subdistal appendage region (PubMed:28659385). .

Expression：Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas.