Target：CEP170

Gene Name：CEP170

Protein Name：Centrosomal protein of 170 kDa

Human Gene Id：9859

Human Swiss Prot No：Q5SW79

Mouse Swiss Prot No：Q6A065

Immunogen：The antiserum was produced against synthesized peptide derived from human CEP170. AA range:701-750

Specificity：CEP170 Polyclonal Antibody detects endogenous levels of CEP170 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CEP170;FAM68A;KAB;KIAA0470;Centrosomal protein of 170 kDa;Cep170;KARP-1-binding protein;KARP1-binding protein

Observed Band(KD)：160kD

Background：centrosomal protein 170(CEP170) Homo sapiens The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008],

Function：function:Plays a role in microtubule organization.,PTM:Phosphorylated; probably by PLK1. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CEP170 family.,similarity:Contains 1 FHA domain.,subcellular location:Associated with the mature mother centriole. Associated with spindle microtubules during mitosis.,subunit:Interacts with PLK1.,

Subcellular Location：Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, spindle . Associated with the mature mother centriole. Associated with spindle microtubules during mitosis. Localizes to the distal appendage region of the centriole (PubMed:31789463). Localizes at the centriole proximal ends (PubMed:31789463). .

Expression： Brain,Cervix carcinoma,Epithelium,Skin,Testis,