Target：CDX2

Fields：Gastric cancer

Gene Name：CDX2

Protein Name：Homeobox protein CDX-2

Human Gene Id：1045

Human Swiss Prot No：Q99626

Mouse Gene Id：12591

Mouse Swiss Prot No：P43241

Immunogen：The antiserum was produced against synthesized peptide derived from human CDX2. AA range:249-298

Specificity：Cdx2 Polyclonal Antibody detects endogenous levels of Cdx2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CDX2;CDX3;Homeobox protein CDX-2;CDX-3;Caudal-type homeobox protein 2

Observed Band(KD)：45kD

Background： This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012],

Function：function:Involved in the transciptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.,PTM:Phosphorylation of Ser-60 mediates the transactivation capacity.,similarity:Belongs to the Caudal homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,

Subcellular Location：Nucleus .

Expression：Detected in small intestine, colon and pancreas.