Target：CDKAL1

Gene Name：CDKAL1

Protein Name：Threonylcarbamoyladenosine tRNA methylthiotransferase

Human Gene Id：54901

Human Swiss Prot No：Q5VV42

Mouse Swiss Prot No：Q91WE6

Immunogen：The antiserum was produced against synthesized peptide derived from human CDKAL. AA range:10-59

Specificity：CDKAL1 Polyclonal Antibody detects endogenous levels of CDKAL1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CDKAL1;Threonylcarbamoyladenosine tRNA methylthiotransferase;CDK5 regulatory subunit-associated protein 1-like 1;tRNA-t(6)A37 methylthiotransferase

Observed Band(KD)：65kD

Background： The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010],

Function：cofactor:Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.,similarity:Belongs to the methylthiotransferase family. CDKAL1 subfamily.,similarity:Contains 1 MTTase N-terminal domain.,similarity:Contains 1 TRAM domain.,

Subcellular Location：Endoplasmic reticulum membrane ; Single-pass membrane protein . Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum. .

Expression：Expressed in pancreatic islets.