Target：CELSR3

Gene Name：CELSR3

Protein Name：Cadherin EGF LAG seven-pass G-type receptor 3

Human Gene Id：1951

Human Swiss Prot No：Q9NYQ7

Mouse Swiss Prot No：Q91ZI0

Immunogen：The antiserum was produced against synthesized peptide derived from human CELSR3. AA range:91-140

Specificity：CDHF11 Polyclonal Antibody detects endogenous levels of CDHF11 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CELSR3;CDHF11;EGFL1;FMI1;KIAA0812;MEGF2;Cadherin EGF LAG seven-pass G-type receptor 3;Cadherin family member 11;Epidermal growth factor-like protein 1;EGF-like protein 1;Flamingo homolog 1;hFmi1;Multiple epidermal growth factor-

Molecular Weight(Da)：358kD

Background： This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013],

Function：function:Does not seem to be involved in anion transport.,function:Receptor that may have an important role in cell/cell signaling during nervous system formation.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.,similarity:Contains 1 GPS domain.,similarity:Contains 1 laminin EGF-like domain.,similarity:Contains 1 STAS domain.,similarity:Contains 2 laminin G-like domains.,similarity:Contains 8 EGF-like domains.,similarity:Contains 9 cadherin domains.,tissue specificity:Ubiquitous. Highest levels in kidney and pancreas. Lower expression in heart, skeletal muscle, liver and placenta. Also found in lung and brain.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression： Brain,Cord blood,Duodenum,Epithelium,Kidney,Uterus,