Target：CDC46

Fields：DNA replication;Cell cycle

Gene Name：MCM5

Protein Name：DNA replication licensing factor MCM5

Human Gene Id：4174

Human Swiss Prot No：P33992

Mouse Swiss Prot No：P49718

Immunogen：The antiserum was produced against synthesized peptide derived from human MCM5. AA range:21-70

Specificity：CDC46 Polyclonal Antibody detects endogenous levels of CDC46 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MCM5;CDC46;DNA replication licensing factor MCM5;CDC46 homolog;P1-CDC46

Observed Band(KD)：90kD

Background： The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008],

Function：similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,

Subcellular Location：Nucleus . Chromosome . Cytoplasm, cytosol . Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. .

Expression： Cervix,Cervix carcinoma,Lymph,Placenta,Spleen,Thymus,Tongue