Target：MACC1

Gene Name：MACC1

Protein Name：Metastasis-associated in colon cancer protein 1

Human Gene Id：346389

Human Swiss Prot No：Q6ZN28

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human MACC1. AA range:411-460

Specificity：MACC1 Polyclonal Antibody detects endogenous levels of MACC1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MACC1;Metastasis-associated in colon cancer protein 1;SH3 domain-containing protein 7a5

Observed Band(KD)：97kD

Background： MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009],

Function：function:Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly found in the cytoplasm in non-metastasizing tumors.,tissue specificity:Preferentially expressed in metastasizing tumors.,

Subcellular Location：Cytoplasm . Nucleus . Mainly found in the cytoplasm in non-metastasizing tumors.

Expression：Preferentially expressed in metastasizing tumors.