Target：MAG

Fields：Cell adhesion molecules

Gene Name：MAG

Protein Name：Myelin-associated glycoprotein

Human Gene Id：4099

Human Swiss Prot No：P20916

Mouse Gene Id：17136

Mouse Swiss Prot No：P20917

Rat Gene Id：29409

Rat Swiss Prot No：P07722

Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human MAG. AA range:501-550

Specificity：MAG Polyclonal Antibody detects endogenous levels of MAG protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MAG;GMA;Myelin-associated glycoprotein;Siglec-4a

Observed Band(KD)：70kD

Background： The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010],

Function：function:Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid.,online information:Siglec-4,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds to RTN4R.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Membrane raft .

Expression：Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures (PubMed:9495552, PubMed:6200494). Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths (PubMed:6200494). Detected in compact myelin (at protein level) (PubMed:6200494). Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system (PubMed:9495552).