Target：Malic enzyme 1

Fields：Pyruvate metabolism;Metabolic pathways;Carbon metabolism;PPAR signaling pathway

Gene Name：ME1

Protein Name：NADP-dependent malic enzyme

Human Gene Id：4199

Human Swiss Prot No：P48163

Mouse Gene Id：17436

Mouse Swiss Prot No：P06801

Rat Swiss Prot No：P13697

Immunogen：The antiserum was produced against synthesized peptide derived from human ME1. AA range:468-517

Specificity：Malic enzyme 1 Polyclonal Antibody detects endogenous levels of Malic enzyme 1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ME1;NADP-dependent malic enzyme;NADP-ME;Malic enzyme 1

Observed Band(KD)：64kD

Background： This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008],

Function：catalytic activity:(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.,cofactor:Divalent metal cations. Prefers magnesium or manganese.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the malic enzymes family.,subunit:Homotetramer.,tissue specificity:Expressed in all tissues tested including liver, placenta and white adipose tissue.,

Subcellular Location：Cytoplasm .

Expression：Expressed in all tissues tested including liver, placenta and white adipose tissue.