Target：Glycerate Kinase

Fields：Pentose phosphate pathway;Glycine, serine and threonine metabolism;Glycerolipid metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Carbon metabolism

Gene Name：GLYCTK

Protein Name：Glycerate kinase

Human Gene Id：132158

Human Swiss Prot No：Q8IVS8

Mouse Gene Id：235582

Mouse Swiss Prot No：Q8QZY2

Rat Gene Id：684314

Rat Swiss Prot No：Q0VGK3

Immunogen：The antiserum was produced against synthesized peptide derived from human GLCTK. AA range:101-150

Specificity：Glycerate Kinase Polyclonal Antibody detects endogenous levels of Glycerate Kinase protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GLYCTK;HBEBP4;LP5910;Glycerate kinase;HBeAg-binding protein 4

Observed Band(KD)：60kD

Background： This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009],

Function：catalytic activity:ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate.,disease:Defects in GLYCTK are the cause of D-glyceric acidemia [MIM:220120]. It is characterized by nonketotic hyperglycinemia with the excretion of D-glyceric acid in the urine and the presence of this substance in the serum.,similarity:Belongs to the glycerate kinase type-2 family.,tissue specificity:Widely expressed.,

Subcellular Location：[Isoform 1]: Cytoplasm .; [Isoform 2]: Cytoplasm. Mitochondrion .

Expression：Widely expressed.