Target：Calgizzarin
Gene Name：S100A11
Protein Name：Protein S100-A11
Human Gene Id：6282
Human Swiss Prot No：P31949
Mouse Gene Id：20195
Mouse Swiss Prot No：P50543
Rat Gene Id：445415
Rat Swiss Prot No：Q6B345
Immunogen：Synthesized peptide derived from Calgizzarin . at AA range: 30-110
Specificity：Calgizzarin Polyclonal Antibody detects endogenous levels of Calgizzarin protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：S100A11;MLN70;S100C;Protein S100-A11;Calgizzarin;Metastatic lymph node gene 70 protein;MLN 70;Protein S100-C;S100 calcium-binding protein A11
Molecular Weight(Da)：12kD
Background： The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008],
Function：function:Facilitates the differentiation and the cornification of keratinocytes.,miscellaneous:Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins.,PTM:Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Homodimer; disulfide-linked.,
Subcellular Location：Cytoplasm . Nucleus .
Expression： Brain,Epithelium,Keratinocyte,Lung,Mammary carcinoma,Placenta,Urina
