Target：RN135

Gene Name：RNF135 L13

Protein Name：E3 ubiquitin-protein ligase RNF135 (EC 6.3.2.-) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (Riplet)

Human Gene Id：84282

Human Swiss Prot No：Q8IUD6

Mouse Swiss Prot No：Q9CWS1

Rat Swiss Prot No：Q5M929

Immunogen：Synthesized peptide derived from human protein . at AA range: 81-130

Specificity：RN135 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：47kD

Background：ring finger protein 135(RNF135) Homo sapiens The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],

Function：disease:Defects in RNF135 are the cause of RNF135-related overgrowth syndrome. RNF135-related overgrowth syndrome is characterized by overgrowth, learning disability, dysmorphic features and variable additional features.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger.,

Subcellular Location：Cytoplasm . Cytoplasm, Stress granule .

Expression：Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung.