Target：M-CSF

Fields：MAPK signaling pathway;Ras signaling pathway;Rap1 signaling pathway;Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;PI3K-Akt signaling pathway;Osteoclast differentiation;Hematopoietic cell lineage;TNF signaling pathway;Alzheimer disease;Pathways of neurodegeneration - multiple diseases;Rheumatoid arthritis

Gene Name：CSF1

Protein Name：Macrophage colony-stimulating factor 1

Human Gene Id：1435

Human Swiss Prot No：P09603

Mouse Swiss Prot No：P07141

Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human CSF1. AA range:505-554

Specificity：M-CSF Polyclonal Antibody detects endogenous levels of M-CSF protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CSF1;Macrophage colony-stimulating factor 1;CSF-1;M-CSF;MCSF;Lanimostim

Observed Band(KD)：48kD

Background： The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011],

Function：function:Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.,PTM:Glycosylation and proteolytic cleavage yield different soluble forms. A high molecular weight soluble form is a proteoglycan containing chondroitin sulfate.,PTM:Isoform 1 is N- and O-glycosylated. Isoform 3 is N-glycosylated.,subunit:Homodimer or heterodimer; disulfide-linked.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein .; [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.

Expression： Endometrium,Kidney,Pancreatic carcinoma,T lymphoblast,Trophoblast,Urine,