Target：ANFC

Fields：cGMP-PKG signaling pathway;Vascular smooth muscle contraction;Fluid shear stress and atherosclerosis

Gene Name：NPPC CNP2

Protein Name：C-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53]

Human Gene Id：4880

Human Swiss Prot No：P23582

Mouse Swiss Prot No：Q61839

Rat Swiss Prot No：P55207

Immunogen：Synthesized peptide derived from human protein . at AA range: 65-95

Specificity：ANFC Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：13kD

Background： This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015],

Function：function:Vasorelaxant activity. Has a cGMP-stimulating activity.,similarity:Belongs to the natriuretic peptide family.,

Subcellular Location：Secreted.

Expression：[CNP-22]: In the kidney, predominantly expressed in the distal tubular cells (at protein level).