Target：POM121

Fields：Nucleocytoplasmic transport;Amyotrophic lateral sclerosis

Gene Name：POM121

Protein Name：Nuclear envelope pore membrane protein POM 121

Human Gene Id：9883

Human Swiss Prot No：Q96HA1/A6NF01/A8CG34

Mouse Gene Id：107939

Rat Gene Id：113975

Rat Swiss Prot No：P52591

Immunogen：The antiserum was produced against synthesized peptide derived from human POM121. AA range:1197-1246

Specificity：POM121 Polyclonal Antibody detects endogenous levels of POM121 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：POM121;KIAA0618;NUP121;POM121A;Nuclear envelope pore membrane protein POM 121;Nuclear envelope pore membrane protein POM 121A;Nucleoporin Nup121;Pore membrane protein of 121 kDa;POM121B;Putative nuclear envelope pore membrane prote

Observed Band(KD)：125kD

Background： This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013],

Function：domain:Contains F-X-F-G repeats.,function:Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).,similarity:Belongs to the POM121 family.,subcellular location:Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase.,

Subcellular Location：Nucleus, nuclear pore complex . Nucleus membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein . Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase. .

Expression： Brain,Cervix,Lymph,Skin,Teratocarcinoma,Testis,Uterus,