Target：ERAP1

Gene Name：ERAP1

Protein Name：Endoplasmic reticulum aminopeptidase 1

Human Gene Id：51752

Human Swiss Prot No：Q9NZ08

Mouse Gene Id：80898

Mouse Swiss Prot No：Q9EQH2

Rat Gene Id：80897

Rat Swiss Prot No：Q9JJ22

Immunogen：The antiserum was produced against synthesized peptide derived from human ARTS-1. AA range:441-490

Specificity：ERAP1 Polyclonal Antibody detects endogenous levels of ERAP1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ERAP1;APPILS;ARTS1;KIAA0525;Endoplasmic reticulum aminopeptidase 1;ARTS-1;Adipocyte-derived leucine aminopeptidase;A-LAP;Aminopeptidase PILS;Puromycin-insensitive leucyl-specific aminopeptidase;PILS-AP;Type 1 tumor necrosis facto

Observed Band(KD)：107kD

Background： The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010],

Function：catalytic activity:Release of an N-terminal amino acid, Xaa-|-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Met, Cys and Phe.,caution:It is uncertain whether Met-1 or Met-13 is the initiator.,cofactor:Binds 1 zinc ion per subunit.,function:Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regula

Subcellular Location：Endoplasmic reticulum membrane ; Single-pass type II membrane protein .

Expression：Ubiquitous.